Analysis of Antioxidant Effects of Lycopene and Caffeine in Experimentally Induced Renal Ischemia-Reperfusion Injury in Rats

Background: The aim was to investigate the antioxidant effects of lycopene and caffeine in rats exposed renal ischemia/reperfusion injury. Materials Methods: Following right nephrectomy, 60 minutes ischemia followed by reperfusion were performed 200-250 gram Wistar albino used study. 30 before ischemia, (5 mg/kg), (50 mg/kg) + administered intraperitoneally rats. After experiment, 4 ml blood left kidney taken from Tissue malondialdehyde, glutathione peroxidase, superoxide dismutase serum creatinine activities measured biochemically light microscopy findings evaluated histologically. Results: When effect against perfusion injury compared with other groups, a significant decrease found levels lycopene. Caffeine be high, but not statistically. malondialdehyde lower groups than group; although peroxidase no significance found. ischemia-reperfusion group, histopathological damage significantly groups. It that reduced apoptosis, tubular dilatation, epithelium degeneration, glomerular shrinkage, desquame proteinaceous cast amount significantly. Conclusions: While has high efficiency when caffeine, have protective